Dr. Fantus is currently an Associate Member at the
Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, as well
as a Senior Scientist at the Toronto General Hospital Research
Institute and Director of the Core Laboratory of the Banting and Best
Diabetes Centre at the University of Toronto.
clinical work in endocrinology and on Type 2 diabetes is located at the
Mount Sinai Hospital/University Health Network, Division of
Endocrinology and Metabolism.
lab, Dr. Fantus uses cultured cells and mouse models to investigate the
molecular mechanism of insulin resistance and the toxic effects of high
glucose that accompany diabetes. He is looking into the role of various
kinases, phosphatases and signaling pathways that are responsible for
sensitizing cells to the effects of insulin.
Lunenfeld-Tanenbaum Research Institute
871-600 University Avenue
Toronto ON M5G 1X5
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Fantus' lab aims to determine the mechanisms behind insulin
resistance toward new treatments and methods to prevent insulin
research interests include the mechanism of insulin signal
transduction, with a specific focus on insulin resistance and Type 2
also investigates various molecular complications involved in diabetes,
specifically diabetic nephropathy.
he received the Young Scientist Award from the Canadian Diabetes
Association, and he has published over 100 articles.
Dr. Fantus has discovered ways by which
abnormal glucose metabolism due to hyperglycemia can alter gene
expression. Studies are carried out in insulin-resistant target
tissues, adipocytes and muscle cells to determine changes in enzyme
activation, protein-protein interactions and glucose
Dr. Fantus' lab also undertakes
investigations to define the pathogenesis of diabetic nephropathy. His
work on this includes studying the effects of high glucose on cell
signaling, oxidative stress, excess O-glycosylation and abnormal gene