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Dr. Laurence Pelletier
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Dr. Laurence Pelletier



Research Institute
Mount Sinai Hospital
Joseph & Wolf Lebovic Health Complex
600 University Avenue
Toronto Ontario M5G 1X5

Tel: 416-586-4800 ext.6196
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Dr. Laurence Pelletier 

Dr. Laurence Pelletier is a Senior Investigator in the Lunenfeld-Tanenbaum's Centre for Systems Biology, where he studies molecular mechanisms in cells that regulate cell division. A better understanding of these fundamental processes has important implications for chromosomal diseases and for cancer.

Dr. Pelletier's research brings together the power of the Human Genome Project with leading-edge microscopy of living cells. He uses these technologies to identify and study the components of the cell involved in cell division, and to investigate their role in healthy development and diseases. 

In August 2008, the Lunenfeld-Tanenbaum received the OMX (Optical microscopy eXperimental) -- one of the world's highest-resolution light microscopes and the only one of its kind in Canada. The OMX uses lasers, high-speed cameras and computers to produce impressive images and gives scientists the clearest view ever seen of cells in real time. This will help researchers study and better understand a variety of biological systems and ultimately help unlock some answers to cancer and birth defects.




At a Glance

  • Studies molecular mechanisms in cells that regulate cell division
  • Holds the Canada Research Chair in Centrosome Biogenesis and Function
  • Seeks a better understanding of processes involved in chromosomal disease (like Down's Syndrome) and cancer
  • Works with the most powerful light microscopes in the world to view proteins working in living cells


Major Research Activities

The focus of Dr. Pelletier's lab is to understand how centriole duplication is regulated during the cell cycle and how centrioles template the formation of cilia and flagella in specialized cells. By organizing pericentriolar material, centrioles orchestrate bipolar mitotic spindle assembly, a prerequisite for the faithful and accurate segregation of chromosomes, failure to tightly regulate the number of centrioles in the cell leading to aneuploidy and contribution to cancer formation.  Using functional genomics in combination with cutting-edge microscopy of live cells, the major goal of our laboratory is to identify and study novel proteins required for these processes and investigate their potential role in development and diseases.


Recent Publications


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