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Dr. John Roder
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Dr. John Roder

dr. john roder

Lunenfeld- Tanenbaum
Research Institute
Mount Sinai Hospital
Joseph and Wolf Lebovic Health Complex
600 University Avenue
Toronto Ontario M5G 1X5

Tel.: 416-586-8241
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Dr. John Roder

Dr. John Roder is an acclaimed neuroscientist at the Lunenfeld-Tanenbaum Research Institute, known worldwide for his pivotal research in brain illnesses such as schizophrenia and depression, as well as learning and memory.

Dr. Roder's ultimate goal is to discover new treatments for schizophrenia, anxiety, epilepsy, depression, and other mental disorders.His research focuses on the roles of molecules in the central nervous system and aims to determine targeted new drug therapies for neurological and psychiatric disease. He has carried out genome-wide forward and reverse genetic screens of ENU mutagenized mice. The Roder lab is also focused on identifying new genes, synapse and signaling pathways that contribute to learning and memory.

In a groundbreaking study in 2007, Dr. Roder demonstrated for the first time in mouse models that malfunction of the gene DISC 1, previously associated with schizophrenia and depression, does, in fact, cause symptoms of those disorders.

In 2013, Dr. Roder was profiled in the TVO documentary film called Do you really want to know?,  an inspirational testament to the emotional and psychological journey of predictive genetic testing, and to his unwavering commitment toward a cure for Huntington's disease. Dr. Roder was diagnosed with Huntington’s disease 16 years ago after having watched both his father and grandfather succumb to the illness while just in their 50s.

Dr. Roder continues to publish groundbreaking research papers, mentors scientist trainees and exercises daily to help control his symptoms. He is steadfast in his fight again Huntington’s - in fact, Dr. Roder has already contributed to significant progress in unravelling the genetics of Huntington’s by understanding why a specific genetic mutation leads to this illness in mice.




At a Glance

  • Ultimate goal is to discover new treatments for schizophrenia, anxiety, epilepsy, depression and other mental disorders
  • Researches the roles of molecules in the central nervous system
  • Holds a Canada Research Chair in Learning and Memory
  • Professor in the Department of Molecular Genetics at the University of Toronto


Major Research Activities

Dr. Roder is exploring the link between long ­term potentiation (LTP), synaptic and learning and memory using engineered mice that lack the glutamate receptors. His lab is focusing on the steps of the complex cascade of events that lead to LTP. Specifically, the Roder lab is examining the means by which NMDA, AMPA and metabotropic glutamate receptors, and their downstream signalling cascades, act to regulate synaptic strength.


Recent Publications


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Ontario Health Study Faculty of Medicine, University of Toronto. mitacs honorary partner


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