Mount Sinai Hospital
Joseph and Wolf Lebovic Health Complex
600 University Avenue
Toronto Ontario M5G 1X5
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Dr. John Roder
Dr. John Roder is an acclaimed neuroscientist at the
Lunenfeld-Tanenbaum Research Institute, known worldwide for his pivotal
research in brain illnesses such as schizophrenia and depression, as
well as learning and memory.
Dr. Roder's ultimate goal is to discover new treatments for
schizophrenia, anxiety, epilepsy, depression, and other mental
disorders.His research focuses on the roles of molecules in the central
nervous system and aims to determine targeted new drug therapies for
neurological and psychiatric disease. He has carried out genome-wide
forward and reverse genetic screens of ENU mutagenized mice. The Roder
lab is also focused on identifying new genes, synapse and signaling
pathways that contribute to learning and memory.
In a groundbreaking study in 2007, Dr. Roder demonstrated for the
first time in mouse models that malfunction of the gene DISC 1,
previously associated with schizophrenia and depression, does, in fact,
cause symptoms of those disorders.
In 2013, Dr. Roder was profiled in the TVO documentary film called
Do you really want to
know?, an inspirational testament to the emotional and
psychological journey of predictive genetic testing, and to his
unwavering commitment toward a cure for Huntington's disease. Dr.
Roder was diagnosed with Huntington’s disease 16 years ago after
having watched both his father and grandfather succumb to the illness
while just in their 50s.
Dr. Roder continues to publish groundbreaking research papers,
mentors scientist trainees and exercises daily to help control his
symptoms. He is steadfast in his fight again Huntington’s - in fact,
Dr. Roder has already contributed to significant progress in
unravelling the genetics of Huntington’s by understanding why a
specific genetic mutation leads to this illness in mice.