Dr. Chen Wang
Dr. Chen Wang is a hematopathologist and Head, Division of
Hematology, Department of Pathology and Laboratory Medicine, Mount
Sinai Hospital. He is an Associate Professor, Lab Medicine and
Pathobiology, University of Toronto.
He obtained his medical degree from Harbin Medical University,
China, and his PhD from the University of Toronto.
His research is focused mainly on lymphocytic neoplasms. In studies
of clinical lymphocytosis with flow cytometry and molecular clonality
assay, his studies have demonstrated that clonal expansion of B- and
T-cell clonopathy. His team also developed a direct lysis PCR method
for clonality detection, increasing detection of B cell lymphoma in
small or body fluid samples.
Dr. Wang led a team that identified breakpoint sequences linking
CDK/6 and IGK genes in a monoclonal B lymphocytosis, and later
pinpointed these sequences in a range of clinical B-cell malignancies.
This genetic overlap points to deregulation of CDK6 as a common
molecular mechanism in clonal B-cell proliferation.
His studies also provided the first identification of a non-CLL type
CD5-negative clonal lymphocytosis, now recognized as a unique type of
monoclonal B lymphocytosis and included in diagnosis guidelines for
In collaboration with investigators at the University of Toronto,
Dr. Wang developed Raman nanoparticles targeting leukemia cells and
developed a flow cytometry method to assess this, and achieved triplex
Raman nanoparticle labelling of leukemia cells.
He holds visiting professorships at Beijing University Stem Cell
Center and at Harbin Medical University, China.