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Mount Sinai Hospital
600 University Avenue
Toronto, Ontario
M5G 1X5
Tel.: 416-586-4800
► Web of Science Researcher ID
J-2346-2016
Dr. Chen Wang
SENIOR CLINICIAN SCIENTIST
Dr. Chen Wang is a hematopathologist and Head, Division of Hematology, Department of Pathology and Laboratory Medicine, Mount Sinai Hospital. He is an Associate Professor, Lab Medicine and Pathobiology, University of Toronto.
He obtained his medical degree from Harbin Medical University, China, and his PhD from the University of Toronto.
His research is focused mainly on lymphocytic neoplasms. In studies of clinical lymphocytosis with flow cytometry and molecular clonality assay, his studies have demonstrated that clonal expansion of B- and T-cell clonopathy. His team also developed a direct lysis PCR method for clonality detection, increasing detection of B cell lymphoma in small or body fluid samples.
Dr. Wang led a team that identified breakpoint sequences linking CDK/6 and IGK genes in a monoclonal B lymphocytosis, and later pinpointed these sequences in a range of clinical B-cell malignancies. This genetic overlap points to deregulation of CDK6 as a common molecular mechanism in clonal B-cell proliferation.
His studies also provided the first identification of a non-CLL type CD5-negative clonal lymphocytosis, now recognized as a unique type of monoclonal B lymphocytosis and included in diagnosis guidelines for this disease.
In collaboration with investigators at the University of Toronto, Dr. Wang developed Raman nanoparticles targeting leukemia cells and developed a flow cytometry method to assess this, and achieved triplex Raman nanoparticle labelling of leukemia cells.
He holds visiting professorships at Beijing University Stem Cell Center and at Harbin Medical University, China.
At a Glance
Hematopathologist and Head, Hematology, Department of Pathology and Laboratory Medicine, Mount Sinai Hospital
Identified a novel genetic breakpoint in B-cell malignancies and a new method to detect B cell lymphoma
With collaborators developed a microfluidics system for characterization of single blood cells and for analysis of red blood cells after storage in a blood bank
Major Research Activities
Dr. Wang’s research interests encompass clinical studies of clonal B- and T-cell lymphocytosis, molecular characterization of a recurrent t(2;7) translocation in B-cell neoplasms, and clinical and laboratory studies on a novel entity of monoclonal B-cell lymphocytosis, and developing nanoparticle-based probes and microfluidics devices for blood cell analysis. He is currently leading an international group of collaborators in a Canadian Space Agency (CSA)-funded study to assess the impact of long-duration space flight on the human immune system.
